∵实数x、y、z满足x2+y2+z2=4,∴(2x-y)2+(2y-z)2+(2z-x)2=5(x2+y2+z2)-4(xy+yz+xz)=20-2[(x+y+z)2-(x2+y2+z2)]=28-2(x+y+z)2≤28∴当x+y+z=0时(2x-y)2+(2y-z)2+(2z-x)2的最大值是28.故选C.